Trimipramine Maleate

Trimipramine Maleate is used for the treatment of depression. This helps improves your mood and sense of well-being and lets you enjoy more of your everyday life. Trimipramine Maleate is a tricyclic antidepressant that restores the balance of a certain natural substance in the brain. The Food and Drug Administration (FDA) has already approved this prescription. Trimipramine Maleate comes as a tablet for oral use with the dosage strengths of 25 mg, 50 mg, and 100 mg. 

Depression is classified as a mood disorder and may be described as feelings of loss, sadness, or anger that interfere with a person’s everyday activities. People experience depression in different ways; 

  1. Daily work which results in lost time and lower productivity
  2. Relationships
  3. Chronic health problems 

It’s important to realize that feeling down at times is a normal part of life. Being upset or sad happens to everyone. But, if you’re feeling hopeless or down regularly, you could be dealing with depression. This type of condition is considered a serious medical condition that can get worse without proper treatment. Depression can be more than a constant state of sadness or feeling blue. The symptoms of depression can be experienced differently among men, women, and children. Signs and symptoms may include:

  • Aggressiveness, anger, anxiousness
  • Feeling sad, empty, hopeless
  • Loss of interest, withdrawing from social engagements
  • Thoughts of suicide
  • Thinking or talking more slowly
  • Decreased energy, sleeping too much, waking up early
  • Greater fatigue, increased cramps, changes in appetite
  • Weights changes, headache, aches or pain 
  • Reduced sexual desire, inability to concentrate
  • Delayed responses during conversations 
  • Drinking excessively or engaging in high-risk activities 

There are lots of things people can do to help decrease the symptoms of depression. For several people, consistent exercise benefits a positive feeling and improves mood. Eating a healthy diet, having enough quality sleep regularly, and avoiding alcohol can also help lessen symptoms of depression. 

How does Trimipramine Maleate work?

Trimipramine Maleate works by enhancing the activity of neurotransmitters called noradrenaline and serotonin in the brain. Serotonin is connected to the regulation of sleep and mood. Noradrenaline is responsible for how the person reacts to anxiety and stress. It is also associated with the fight-or-flight response. 

Neurotransmitters are natural body chemicals that act as chemical messengers between the nerve cells. In depression, less noradrenaline and serotonin than normal is released from nerve cells in the brain. Trimipramine Maleate prolongs the effects of noradrenaline and serotonin that have been released in the brain. Over time, this helps to lighten the mood and relieve depression. 

This medication won’t change your personality or make you feel instantly happy and relaxed. This works over time to correct the chemical changes in your brain that have made you depressed. Trimipramine Maleate also helps you get back to feeling like your old self. 

How to use Trimipramine Maleate?

Dosage is based on your medical condition and response to therapy. Your doctor may start you at a low dose and gradually increase your dose. Use this medication regularly to get the most benefit from it. It is important to continue taking this medication even if you feel well.

Take this medication by mouth with or without food, usually 1-3 times a day. If taking this medication once a day, take it at bedtime to lessen the risk of drowsiness. 

Trimipramine Maleate does not work right away. It may take 2 to 4 weeks before you experience the full benefits. To help you remember, use it at the same time each day. You should not stop quickly taking this medication without the consultation of your doctor. Certain disorders may get worse when the medication is stopped. Your dosage might need to be slowly reduced. Inform your doctor if your condition does not improve or if it worsens. If you missed a dose, call your doctor right away for instructions. Do not double the dose to make up for your missed dose. 

What are the side effects of Trimipramine Maleate?

Common side effects:

  • Sleep problems or insomnia
  • Blurred vision
  • Dizziness
  • Drowsiness
  • Numbness or tingling in your hands or feet 
  • Vomiting
  • Nausea
  • Dry mouth
  • Loss of appetite
  • Changes in weight
  • Breast swelling in men or women 

Call your doctor right away if these side effects occur:

  • Blurred or tunnel vision
  • Eye pain or swelling
  • New or worsening chest pain
  • Seeing halos around lights
  • Unusual thought or behavior
  • Painful or difficult urination
  • Pounding heartbeats or fluttering in your chest 
  • Unusual bruising or bleeding
  • A light-headed feeling like you might pass out
  • Sudden weakness or ill feeling
  • Chills or fever sore throat
  • Restless muscle movements in your eyes, jaw, tongue, or neck
  • High levels of serotonin in the body (loss of coordination, agitation, nausea, diarrhea, vomiting, or fainting)

Warnings and Precautions

  • Trimipramine Maleate may cause dizziness, drowsiness, or problems concentrating, and blurred vision. It could reduce your ability to drive safely. Do not drive if affected. 
  • This medication can sometimes make you feel dizzy or unsteady when you get up from lying down or sitting. Try to get up slowly to avoid this. 
  • Trimipramine Maleate may make your skin more sensitive to sunlight than usual. Do not use sunbeds or sunlamps and avoid exposing your skin to excessive amounts of strong sunlight until you know how it affects you. 
  • You should avoid drinking alcohol while taking this medicine. It will make you more likely to feel dizzy, sleepy, or confused. This effect is likely to be worse if you drink alcohol when you start treatment or after any dose increases. 
  • This should not be recommended for use in children under 18 years of age, people with severe liver disease, heart disease, bipolar disorder, or with rare hereditary blood disorders. 
  • This should not be taken by people who are allergic to any ingredient of Trimipramine Maleate. 
  • A lower dose and extra monitoring are needed in people with liver problems, overactive thyroid gland, those who have difficulty passing urine, and with diabetes. 
  • For those with chronic constipation or psychotic illnesses, this medication should as well be used carefully.