Trientine Hydrochloride

Where is Trientine Hydrochloride used?

Trientine Hydrochloride is a chelating agent that is used for the treatment of a certain inherited disorder called Wilson’s disease. A chelating agent binds to copper which helps your body get rid of extra copper. This helps lessen the symptoms of Wilson’s disease. The FDA has already approved this prescription.

How does Trientine Hydrochloride work?

Trientine Hydrochloride is the hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. This drug chelates excess copper in the body. Through the kidneys, the extra copper is then detached from the body. 

An additional copper accrues perhaps because the liver wants the mechanism to defecate free copper into the bile. Hepatocytes supply extra copper but then when their capacity is exceeded copper is released into the blood and is taken up into extrahepatic sites. Wilson’s disease is treated to help its excretion from the body with the use of chelating agents that bind copper.  It can also be with a low copper diet.

How is Trientine Hydrochloride taken?

Trientine Hydrochloride is given on an empty stomach. It can be an hour before meals or two hours after meals. This can be taken at least one hour apart from any other medications, milk, or food. The capsules should be swallowed whole with water and should not be opened or chewed. It is because of the possible contact dermatitis, every site of contact to the capsule contents must be washed with water quickly. The dosage is based on your medical condition and response to the treatment. Follow a low-copper diet as directed by your doctor for the best effect.

For the first month of treatment, check your temperature every night and let your doctor know of any fever or rash. If your doctor directs you to also take an iron supplement, take it at least 2 hours before or after Trientine Hydrochloride. Tell your doctor if your condition does not get better or if it gets worse.

What are the precautions in taking Trientine Hydrochloride?

  • This drug is contraindicated in patients’ hypersensitivity to it or any components of the formulation. Patients should be observed closely for signs of possible hypersensitivity.
  • It is not known yet if this drug is excreted in human milk. Several medications are emitted in human milk. Cautiousness must be applied when Trientine Hydrochloride is given to a nursing mother. 
  • A mineral supplement is not recommended since it might block the absorption of this medicine.
  • Ask your doctor before using a mineral supplement or vitamin and use only what your doctor recommends. Several minerals could make it tougher for your body to absorb Trientine Hydrochloride.
  • While having this medication, you may need frequent blood and urine tests. You should remain under the care of a doctor during treatment. 
  • To make sure that this drug is safe for you, let your doctor know if you have a liver condition called biliary cirrhosis or anemia. 
  • During pregnancy, this medication should only be used when needed. Discuss the risks and benefits with your doctor.