What condition does Ruxolitinib treat?

Ruxolitinib is recommended for use on certain bone marrow disorders such as:

  • Polycythemia Vera

This is a slow-growing blood cancer in which your bone marrow creates a lot of red blood cells. These cells thicken your blood and slowing its flow. They may also cause complications like blood clots. That it leads to a heart attack or stroke.

  • Myelofibrosis

This is an unusual type of bone marrow cancer that interrupts your body’s normal making of blood cells. It causes extensive scarring in your bone marrow leading to severe anemia that can cause weakness.

This medication is not a cure for these disorders, but it may help with some of the symptoms such as:

  • Night sweats
  • Bone or muscle pain
  • Itching
  • Pain under left ribs
  • Abdominal discomforts
  • Early feelings of fullness from meals

Ruxolitinib belongs to the class of medications called JAK inhibitors. This comes as a tablet for oral use. The U.S. Food and Drug Administration (FDA) has already approved this prescription.  

How does Ruxolitinib work?

Ruxolitinib is a kinase inhibitor that is selective for the Janus Associated Kinases (JAK) 1 and 2. These are responsible for the mediation of cytokine and growth factor signaling. Wherein, it affects immune function and hematopoiesis. The signaling process involves signal transducers and transcriptions activators (STAT). In which it is the one that modulates the gene expression. People with Myelofibrosis have abnormal JAK1 and JAK2. Thus, this medication works to regulate this condition.

What is the recommended dosage for Ruxolitinib?

Ruxolitinib Tablet is to be taken by mouth with or without a meal. Each dose is usually taken twice a day. If you have difficulty swallowing the tablet as a whole, call your doctor for another way to take it. Remember to take each tablet at the same time every day.

The dosage is based on your medical condition and response to it. Take it exactly as it is prescribed. Do not take more than or more often than it is directed by your doctor.

What are the side effects of Ruxolitinib?

  • Dizziness
  • Bruising
  • Weight gain
  • Headache
  • Gas
  • Bloating
  • Fatigue
  • Anemia
  • Diarrhea
  • Nausea
  • Shortness of breath
  • Body aches
  • Sores in your mouth or throat
  • Pale skin
  • Flu symptoms

What are the precautions in taking Ruxolitinib?

  • Before using this medication, tell your doctor if you have a medical history of kidney or liver disease.
  • Do not have vaccinations or immunizations without the consent of your doctor. Avoid contact with those who have recently received live vaccines.
  • Do not drive or perform any activity that requires alertness. This medicine may make you dizzy.
  • Limit alcoholic beverages while using this prescription. Alcohol can make you dizzier. Alcohol also makes you more at risk for certain side effects.
  • If you are a pregnant or breastfeeding woman, consult your doctor first before using. This medication may not be recommended for use.
  • Avoid eating grapefruit or drinking grapefruit juice. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.
  • Keep this at room temperature away from heat and moisture.