Where is Metolazone used?

Metolazone is a type of diuretic that is used to treat high blood pressure. This is also used to treat the build-up of excess fluid and salt in your body. Metolazone may be taken as part of combination therapy with other medications.

Diuretics cause you to urinate more. This helps remove excess fluid and salt from your body. Removing excess fluid and salt also helps lower your blood pressure. 

How does Metolazone work?

Diuretics remove extra fluid from the body by increasing the production of urine. They work by causing the kidneys to increase the number of salts that are filtered out of the blood and into the urine. Diuretics draw water alongside them once these salts are removed out of the blood by the kidneys. As diuretics increase the removal of salts from the blood, they also cause more water to be drawn out of the blood into the urine. 

Eliminating water from the blood reduces the volume of fluid circulating through the blood vessels. This subsequently decreases the pressure within the blood vessels. Therefore, this drug works effectively in lowering high blood pressure. 

How is Metolazone taken?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor. Your doctor might sometimes change your dose to make sure you get the best results from this medication.

This medication is taken by mouth with or without food. The dosage is based on your medical condition and response. You may need to wake up to urinate if you take this too close to bedtime. It is best to take this medicine at least 4 hours before your bedtime. Let your doctor know if your condition does not improve or gets worse. 

What are the precautions in taking Metolazone?

  • Metolazone can sometimes be used together with the diuretic furosemide. This will cause large volumes of urine to be produced. Your blood pressure and levels of salts in your body must be carefully monitored. 
  • This medicine may cause dizziness. You should be careful when performing some activities. 
  • While having this drug, you may need to have regular blood tests to monitor your kidney function. Your levels of salts in your blood should also be monitored. 
  • Metolazone can sometimes cause the level of sodium in your blood to fall too low. For this reason, following a very strict low salt diet should be avoided while you are taking this medicine.
  • This medicine should be used with caution in elderly people, people with diabetes, a history of gout, who are malnourished, and with hereditary blood disorders called porphyrias. 
  • This drug is not recommended for use in people with reduced levels of consciousness due to liver cirrhosis, whose kidneys are not producing urine, with a high level of potassium or sodium, or in people with a high level of calcium in their blood. 
  • Inform your doctor first if you are breastfeeding, pregnant, or planning to become pregnant before taking this medication.