Macitentan

What condition does Macitentan treat?

Macitentan is used for the treatment of high blood pressure in the lungs called pulmonary arterial hypertension. This type of condition is thought to be caused by increased levels of endothelin-1. This medication blocks the effects of endothelin-1 that helps lessen the blood pressure in the lungs. Macitentan also slows the worsening of symptoms from the disease.

This is a prescription approved by the U.S. Food and Drug Administration (FDA) in 2013. Macitentan is an endothelin receptor antagonist. This helps your heart pump blood more efficiently. Macitentan also improves your ability to exercise and prevents high blood pressure in the lungs from getting worse. This is supplied as a film-coated tablet for oral use. 

How does Macitentan work?

Macitentan works by blocking endothelin. It is a substance made by the body. Endothelin causes blood vessels to narrow. It also causes abnormal growth of the muscle in the walls of the blood vessels in the lungs. In order for the blood to reach the lungs, the narrowing increases the pressure needed. Moreover, Macitentan reduces the blood pressure in the lungs by blocking the action of endothelin. By doing so, it reduces disease progression.

What is the recommended dosage for Macitentan?

The recommended dosage is based on your medical condition and response. This is to be taken exactly as it is prescribed for the best benefit. Do not increase your dose or use this more often or for longer than prescribed.  

Macitentan is usually taken once a day. You may take each dose with or without food. With a full glass of water, swallow the medicine as a whole. Do not chew or break the drug. Don’t forget to take it at the same time each day. Tell your doctor if your condition does not improve or if it gets worse. If you missed a dose, call your doctor for instructions. Do not take two doses to make up for the missed dose.

What are the side effects of Macitentan?

  • Headache
  • Flu
  • Common cold symptoms (sore throat or stuffy nose)
  • Decreased in the amount of urine
  • Pale skin
  • Dark urine
  • Muscle pain or aches
  • Weight gain
  • Unusual tiredness or weakness
  • Unusual bruising or bleeding

What are the precautions in taking Macitentan?

  • Do not use this medication if you are allergic to it.
  • This is not recommended if you are breastfeeding women.
  • Inform your doctor if you have anemia, liver, or kidney disease.
  • Before taking a dose, let your doctor know if you have any medical history or current medication.
  • Inform your health care provider or pharmacist if you are taking especially St. John’s wort.  
  • If there are any signs of an allergic reaction, call for medical help right away.
  • This medication could cause birth defects or could harm an unborn baby. Do not use this medicine if you are pregnant or think you might be pregnant. Tell your doctor right away if you miss a menstrual period or think you may have become pregnant during treatment.
  • Keep this drug away from heat and moisture.