Lumacaftor and Ivacaftor

General Information

Lumacaftor and Ivacaftor are indicated for the treatment of cystic fibrosis in certain people. This is used for those with two copies of an abnormal CFTR gene. Cystic fibrosis is an inherited disorder. It causes severe damage to the digestive system, lungs, and other organs in the body. This condition affects the cells that produce sweat, mucus, and digestive juices. Lumacaftor and Ivacaftor will help improve breathing and lessen the risk of lung infections.

How do Lumacaftor and Ivacaftor work?

Lumacaftor and Ivacaftor work on certain defects of the CFTR protein at the cellular level. Together, these two medicines may help more chloride ions to pass into and out of the cells. That it helps keep a balance of salt and water in certain organs such as the lungs.

Why use Lumacaftor and Ivacaftor?

Lumacaftor and Ivacaftor is a combined medication used for long-term treatment in patients aged 6 years and older. Lumacaftor belongs to the class of medications called cystic fibrosis transmembrane conductance regulator correctors. Ivacaftor is in the class of cystic fibrosis transmembrane conductance regulator potentiators. These drugs help improve the function of the abnormal CFTR protein. The Food and Drug Administration (FDA) has already approved this prescription. This is supplied as tablets for oral use. Each film-coated tablet contains 200 mg of Lumacaftor and 125 mg of Ivacaftor.

How to use Lumacaftor and Ivacaftor?

The recommended dosage is based on your medical condition and response. It is important that you take this medication exactly as it is prescribed. Do not take more often or more than it is given by your doctor.

This is usually taken twice a day with 12 hours apart. Swallow the tablet by mouth with a full glass of water. You may take each dose with or without a meal. Don’t forget to take this drug at the same time every day.

What are the side effects of Lumacaftor and Ivacaftor?

  • Sore throat and stuffy nose
  • Shortness of breath
  • Diarrhea
  • Nausea
  • Fatigue
  • Abnormal breathing
  • Rash
  • Runny nose
  • Flu symptoms
  • Menstrual changes
  • Increases blood pressure

Warnings and Precautions

  • Before taking this medication, let your doctor know if you have any allergies. Tell as well if you have any medical history or current treatments or medications.
  • While taking this, limit alcoholic beverages.
  • If you are pregnant or breastfeeding women, consult your doctor first.
  • This may not be prescribed for other uses. Ask your doctor for more information.
  • Do not suddenly stop taking without the consent of your doctor.