What condition does Lesinurad-Allopurinol treat?
Lesinurad-Allopurinolis an oral medicine used to lower uric acid. This medication helps prevent gout flares. Increased uric acid levels can cause gout attacks.
A gout is a form of inflammatory arthritis that develops in some people who have high levels of uric acid in the blood. The acid can form needle-like crystals in a joint and cause severe episodes of pain, redness, swelling, and tenderness.
Lesinurad and Allopurinol is combined medication that helps lessen the amount of uric acid that your body makes. This also helps the kidneys get rid of uric acid. This is a prescription approved by the Food and Drug Administration (FDA). Lesinurad is a URAT1 inhibitor and Allopurinol is a xanthine oxidase inhibitor.
How does Lesinurad-Allopurinol work?
Lesinurad and Allopurinol inhibit xanthine oxidase. It is the enzyme that converts hypoxanthine to xanthine to uric acid. Inhibition of this enzyme is responsible for the effects of this medication. This drug increases the utilization of hypoxanthine and xanthine for nucleotide and nucleic acid synthesis. It is a process that involves the enzyme hypoxanthine-guanine phosphoribosyltransferase.
This progress results in an increased nucleotide concentration that causes response inhibition of de novo purine synthesis. The result is reduced serum uric acid and urine concentrations, which decreases the incidence of gout symptoms.
What is the recommended dosage for Lesinurad-Allopurinol?
- The recommended dosage for this medication is 400 mg per day
- This drug should not be taken with any other drugs that are used to treat gout or hyperuricemia.
- It’s important to speak with your doctor before taking this medication, as it may interact poorly with certain medications and cause side effects like diarrhea, nausea, vomiting, stomach pain, headache, dizziness, and more
- Your doctor will monitor you while you’re using Lesinurad-Allopurinol to make sure the treatment is working effectively for you.
- If it’s determined that the treatment isn’t effective enough for your needs or if there are serious side effects from the medication then they will adjust your dose accordingly until they find an appropriate balance of efficacy and safety
What are the side effects of Lesinurad-Allopurinol?
- Skin rash
- Chest pain or discomfort
- Double vision
- Slow speech
- Pain or discomfort in the arms, back, jaw, or neck
What are the precautions in taking Lesinurad-Allopurinol?
- Lesinurad-Allopurinol is contraindicated in patients with a known hypersensitivity to Lesinurad or any of the other ingredients.
- Patients should be advised that serious and potentially fatal adverse reactions have been reported in association with allopurinol therapy, including severe skin reactions, life-threatening blood disorders, and liver damage.
- The most common side effects are nausea, vomiting, diarrhea, headache, dizziness.
- It is recommended to take this medication daily for 6 months.
- Lesinurad-Allopurinol has not been studied in pregnant women or children under 18 years old so it should only be used if prescribed by your doctor.
- This drug can cause liver problems which may lead to death if untreated. The symptoms include yellowing of the eyes and skin as well as dark urine. These symptoms could indicate a need for immediate medical care.