General Information

Galsulfase is indicated for the treatment of a rare genetic problem called Maroteaux-Lamy syndrome (MLS). MLS is an inherited disease caused by a deficiency in the enzyme arylsulfatase B. It is responsible for the breakdown of large sugar molecules. This medication replaces certain natural substances that are missing in people with MLS.

How does Galsulfase work?

Galsulfase is intended to increase the catabolism of GAG and provide an exogenous enzyme that will be taken up into lysosomes. This uptake by cells into lysosomes is most likely mediated by the binding of mannose-6-phosphate-terminated oligosaccharide chains of this drug. Specifically, it is mannose-6-phosphate receptors. Therefore it lessens the symptoms of the condition.

Why use Galsulfase?

Galsulfase is in the class of medications called enzyme replacement therapies. This helps replaces the enzyme so that the body can recycle the wastes normally. This is a prescription approved by the Food and Drug Administration (FDA). Galsulfase is supplied as a nonpyrogenic, colorless to pale yellow, sterile, clear to a slightly opalescent solution.  Each vial of this medication provides 5 ml of Galsulfase. This is intended for intravenous infusion.

How to use Galsulfase?

The recommended dosage is based on your medical condition, age, and response. It is important that you take this exactly as it is prescribed. This is to be given slowly into a vein as directed by your doctor. Usually, this is given over hours once a week. Before using, check this product visually for particles or discoloration. Do not shake the medication. If you do not clearly understand how to use Galsulfase, call your doctor. Do not use this prescription more or less than it is given. Remember to use this on the same day and time each week. Tell your doctor if your condition gets worse or does not improve.

What are the side effects of Galsulfase?

  • Joint pain
  • Headache
  • Nausea
  • Eye redness
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Sore throat
  • Stuffy or runny nose
  • Cough
  • Rash or itching
  • Injection site reactions such as redness, swelling, pain, or irritation

Warnings and Precautions

  • Do not give this drug to anyone else even if they have the same symptoms as you do.
  • You should not stop this treatment without the consent of your doctor.
  • This may not be recommended for use in breastfeeding women.
  • Consult your doctor first if you are pregnant women.
  • If there are any allergic reactions occur, call for medical help right away and stop using this drug.
  • Before using, tell your doctor if you have ever had lung problems or heart problems.