Ecallantide Injection

General Information

Ecallantide is used for the treatment of an acute attack called hereditary angioedema (HAE). That is of a certain immune disease passed down through families. This medication may lessen the symptoms of this condition like rapid swelling and pain of the feet, hands, face, limbs, tongue, or throat. When attacks involve the intestines, symptoms may be diarrhea or vomiting and abdominal pain/cramps.

HAE is a disorder characterized by recurrent episodes of severe swelling. The most common area of the body to develop is swelling in the face, limbs, airway, and intestinal tract.

How does Ecallantide work?

Ecallantide blocks an enzyme in the blood called kallikrein. Kallikrein is a part of a complex network of proteins that has several effects in the body. One of which results in increased levels of a protein called bradykinin. It causes the blood vessels to widen and leak fluid into the surrounding tissue. This leakage of fluids causes the swelling attacks seen in angioedema. By blocking the actions of kallikrein, this drug is expected to help lessen the swelling and related symptoms of angioedema.

Why use Ecallantide?

Ecallantide is produced by a method known as recombinant DNA technology. It is made by a cell that has received a gene (DNA) which makes the cell able to produce it. This medication is for injection, subcutaneous use. Each vial contains 10 mg of Ecallantide as an active ingredient. A 30 mg dose is supplied as 3 vials each have 1 ml of 10 mg Ecallantide. This product has the brand name of Kalbitor. The Food and Drug Administration (FDA) has already approved this medication. 

How to use Ecallantide?

This prescription is to be given by your doctor or healthcare professional. This is to be injected under your skin either in the thigh, abdomen, or upper arms. You may receive three shots that are separated by at least 2 inches. An additional three shots may be given in a 24-hour period. It is if the HAE attack continues. The dosage is based on your medical condition and response.

What are the side effects of Ecallantide?

  • Vomiting
  • Nausea
  • Fever
  • Stomach
  • Diarrhea
  • Headache
  • Sore throat
  • Tired feeling
  • Injection site reactions (pain, rash, irritation, redness, bruising, or itching)

Warnings and Precautions

  • Do not receive an injection into the skin that is tender, hard, or red.
  • Tell your doctor if you are allergic to this medication or if you have any allergies.
  • Let your doctor know if your condition does not improve or if it gets worse.
  • This prescription may not be recommended for pregnant women. If you are breastfeeding women, consult your doctor r first.
  • Inform your doctor if you have any medical history.