Where is Diflunisal used?

Diflunisal is used for the treatment of:

  • Mild to moderate pain
  • Osteoarthritis
  • Rheumatoid arthritis

This medicine is for acute or long-term use for symptomatic treatment. This helps reduce swelling, pain, and joint stiffness caused by arthritis. Reducing these symptoms helps you do more of your normal daily activities.

Diflunisal belongs to the group of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). This group of medications is effective in treating pain, inflammation, and fever in the body. This is available in tablets for oral administration. The Food and Drug Administration (FDA) has already approved this medication.

How does Diflunisal work?

Diflunisal works by decreasing the levels of prostaglandins. It is a chemical that is responsible for inflammation, pain, and fever. This drug blocks the enzymes that make prostaglandins (cyclooxygenases). It results in a lower concentration of prostaglandins. As a consequence, inflammation, pain, and fever are reduced. 

How is Diflunisal taken?

The dosage is based on your medical condition and response.

This medication is to be taken by mouth with a full glass of water. Do not lie down for at least 10 minutes after taking the drug. Take it with food or milk or right after meals to prevent stomach upset. Swallow the medication as a whole. Do not chew or break it. Take it at the same time each day or as directed by your doctor. It may take up to 2 weeks of regular use before the full benefits of this drug take effect.

For safe and effective use of this medication, do not take it more often, do not take more of it, and do not take it for longer than recommended by your doctor. Taking too much of this medication may increase the chance of unwanted effects, especially in elderly patients.

What are the possible side effects of Diflunisal?

  • Stomach pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Upset stomach
  • Gas
  • Constipation
  • Drowsiness or dizziness
  • Headache
  • Tired feeling
  • Sleep problems or insomnia
  • Ringing in your ears

What are the precautions in taking Diflunisal?

  • Before using this medication, inform your doctor if you have any medical history or current medications including vitamins or herbal supplements.
  • Tell your doctor if you are allergic to this drug or if you have any allergies.
  • This is not recommended for use in children under 12 years of age.
  • If you are a pregnant or breastfeeding woman, you should consult your doctor first.
  • Do not use this past the expiration date.
  • Before having surgery, inform your doctor that you are using this medicine.
  • This medication may make you drowsy or dizzy. Do not use machinery, drive, or do anything that requires alertness until you can do it safely.
  • This medication may cause stomach bleeding. Everyday use of alcohol may increase your risk for stomach bleeding, especially when taken along with this medicine. Limit alcohol. Consult your doctor for more information.
  • The elderly may be more sensitive to the side effects of this medication, especially stomach or intestinal bleeding as well as kidney complications.