CHLOROQUINE

The CORONA VIRUS-19 (COVID-19) is an infectious disease caused by the transmission of the virus. The main symptom of it is severe acute respiratory syndrome. The origin of the COVID-19 was identified in Wuhan, China. Since then the Coronavirus has spread globally and become pandemic in a short period. The infection caused by the CORONA virus can spread fast from one person to another.

The spreading of the CORONA virus happens through coughing and sneezing.  The onset of the symptoms from the exposure is 2 weeks.  The standard method of diagnosis is by a reverse transcription-polymerase chain reaction. The rate of deaths per number of diagnosed cases is on average 3.4%. The infection is also diagnosed with a combination of symptoms. The COVID-19 commonly attacks those who have a weak immune system.

The symptoms of COVID-19

  • Fever and muscle pain
  • Production of sputum
  • Sore throat and dry cough
  • Severe symptoms are pneumonia and organ failure
  • Cough and shortness of breath               

What is Chloroquine?                                                                                           Chloroquine is a medication used to prevent and to treat malaria. It treats certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines. Amebiasis is a parasitic infection of the intestines caused by the protozoan Entamoeba. The symptoms of amebiasis include loose stool, abdominal cramping, and stomach pain. This medication is only allowed upon the prescription of a doctor.

Chloroquine is also used for rheumatoid arthritis and lupus erythematosus. There is also a continuous study wherein the Chloroquine can treat the COVID-19. COVID-19 has no specific treatment for now however the Chloroquine can aid in dealing with most of the symptoms. It is still recommended to use and apply precautionary measures. Managing the COVID-19 involves supportive care, isolation, and experimental measures.

Chloroquine is not a treatment for bacterial and allergic infections. Do not take this if you are allergic to any of its ingredients. You must also stop using this when you experience allergic reactions. Always visit your doctor from time to time during your treatment.  You must avoid crowded and dirty places. The Chloroquine must be stored in a cool dry place.

How does Chloroquine work?

Chloroquine works by interfering with the growth of parasites in the red blood cells of the human body. It has been used for autoimmune diseases. This is because of its profound immunomodulatory effects. The CIOVID-19 targets the immune system and host that has existing diseases. Chloroquine can inhibit a pre-entry step of the viral cycle. This is done by interfering with viral particles binding to their cellular cell surface receptor.

Chloroquine can also impair another early stage of virus replication. This is done by interfering with the pH-dependent endosome-mediated. This will guard the viral entry of enveloped viruses. Chloroquine can also interfere with the post-translational modification of viral proteins. These modifications which involve proteases occur within the endoplasmic reticulum or the trans-Golgi network. This may also require a low pH.

Chloroquine can also act on the immune system. This is done by sending signals to the cells and regulating them through the cell of pro-inflammatory cytokines. The work of the Chloroquine is also based on the age, weight, and severity of the illness. The onset of the effects of the Chloroquine can be observed right away.

Taking Chloroquine with other medicine

  • The Chloroquine may lower the effectiveness of vaccines such as rabies. It lowers the vaccines that are administered into the skin. have your vaccine ahead of time or before you will take the Chloroquine.
  • The Antacids that are used to treat indigestion and heartburn can reduce the absorption of chloroquine from the gut. This may mean the full dose is not absorbed into the body. To avoid such a situation you have to take the antacid ahead of time.
  • Cimetidine can also prevent the breakdown of chloroquine by the liver. This eventually leads to an increased level of chloroquine in the blood. You should avoid taking cimetidine with chloroquine as it may increase the risk of side effects. Let your doctor know if you are recently taking Cimetidine.

How to use the Chloroquine?

Take this medication by mouth after eating your meal. You have to take this as directed by your doctor. The Chloroquine has specific weekly dosing. The length of the treatment is still being studied but you have to base it on your medical condition. Stick to the duration of dose and do not take it if you go beyond the dosage period. Follow your doctor’s instructions to avoid the worst side effects. You also have to take it ahead of other medications you have.

The Chloroquine should be used in caution with elderly people. Tell your doctor if you have existing diseases such as kidney and liver diseases. People with severe gut disorders and diabetes must observe proper treatment. This is not allowed for breastfeeding or pregnant women. Inform your doctor if you just had surgery or you just gave birth. You can buy Chloroquine online.

Common and Serious Side Effects of Chloroquine

  • The common side effects of the Chloroquine are:
  • Blurred vision, nausea, and vomiting
  • Abdominal cramps and headache
  • Diarrhea may also occur

If these mild symptoms persist inform your doctor. Below is the list of the severe side effects of the Chloroquine:

  • Bleaching of hair color
  • Hair loss and mental/mood changes
  • Confusion, personality changes, and unusual behavior
  • Depression, hearing changes or hearing loss
  • Darkening of skin and tissue inside the mouth
  • High fever and severe chills
  • Persistent sore throat and unusual tiredness
  • Shortness of breath and pale lips/nails/skin

Precautions in taking Chloroquine

  • Take this medication exactly as prescribed by your doctor
  • Do not take more or less of this drug than prescribed
  • Do not stop taking it before completing treatment
  • Skipping or changing your dose may affect the treatment
  • Avoid being bitten by mosquitoes and other parasitic organisms
  • Stay away from people when you experience sneezing and cough
  • Self-quarantine should be observed in on-going treatment
  • Keep this away from the sight and reach of children

https://www.news.com.au/lifestyle/health/health-problems/coronavirus-australia-queensland-researchers-find-cure-want-drug-trial/news-story/93e7656da0cff4fc4d2c5e51706accb5

https://www.businessinsider.com/malaria-pill-chloroquine-tested-as-coronavirus-treatment-2020-3

https://www.sciencedirect.com/science/article/pii/S0924857920300881?via%3Dihub

https://www.unboundmedicine.com/medline/research/Chloroquine_AND_(Coronavirus_2019_OR_COVID-19_OR_SARS-CoV-2)

https://www.webmd.com/drugs/2/drug-8633/chloroquine-oral/details

https://www.ncbi.nlm.nih.gov/pubmed/25477006

https://www.news.com.au/lifestyle/health/health-problems/coronavirus-australia-queensland-researchers-find-cure-want-drug-trial/news-story/93e7656da0cff4fc4d2c5e51706accb5

https://www.netdoctor.co.uk/medicines/infection/a6256/avloclor-chloroquine/

Trump, White House Coronavirus Task Force Hold News Conference and included in his speech that this can help in the treatment for COVID-19.

Trump, White House Coronavirus Task Force Hold News Conference | NBC News (Live Stream Recording)