Where is Alogliptin used?

Alogliptin belongs to a group of diabetes medication called DPP-4 inhibitors used to control blood sugar levels with type 2 diabetes mellitus. Controlling high blood sugar helps prevent:

  • Blindness
  • Nerve problems
  • Kidney damage
  • Loss of limbs
  • Sexual function problems

Well-controlled diabetes may also lessen your risk of stroke or heart attack. This medication is used when your blood sugar cannot be sufficiently controlled by exercise, diet, or other antidiabetic medicines. The Food and Drug Administration (FDA) has approved this medication.

How does Alogliptin work?

Alogliptin works by increasing the amount of two incretin hormones, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones are usually made naturally by the body in response to food consumption. Their task is to help control blood sugar levels. GIP and GLP-1 have four main actions that help to control blood glucose.

  • They stimulate the pancreas to create insulin in response to increasing levels of glucose in the blood. Insulin is the leading hormone accountable for controlling sugar levels in the blood. It causes cells in the body to eliminate sugar from the blood.
  • GLP-1 also lessens the fabrication of glucagon which is a hormone that usually increases glucose production by the liver.
  • GIP and GLP-1 decrease the rate at which food passes from the stomach into the intestines. It slows down the absorption of glucose from the gut into the bloodstream. They act on the brain to cause a feeling of fullness that decreases further food intake.
  • GIP and GLP-1 are usually broken down by dipeptidyl peptidase 4. It binds to this enzyme and stops it from breaking down the GIP and GLP-1. This increases the levels of these hormones in the body and so increases their effect on controlling blood sugar.

How is Alogliptin taken?

The recommended dosage for this medication will depend on your condition and response. The usual dose for this medicine is one 25 mg tablet taken once a day by mouth. Each dose can be taken with or without food. Take this at the same time each day. Swallow the tablet as a whole with a glass of water. Follow your doctor’s prescription very carefully. To avoid complications, do not double the dose. If you missed a dose, call your doctor for instructions.

What are the possible side effects of Alogliptin?

  • Itching
  • Dark urine
  • Loss of appetite
  • Nausea
  • Vomiting

What are the precautions in taking Alogliptin?

  • Before taking this prescription, tell your doctor if you are allergic to it or if you have certain allergies.
  • Consult your doctor if you are a pregnant or breastfeeding woman before taking a dose of this drug.
  • Tell to your doctor if you have any medical history or current medications including herbal or food supplements.
  • Do not skip meals if you are taking this medicine.
  • This may make you feel dizzy. Avoid driving or do any activity that needs your alertness until you know how this drug affects you.
  • Do not share this with others who have the same condition as yours.