Valganciclovir

Valganciclovir

Valganciclovir is an antiviral drug used for the treatment of cytomegalovirus (CMV) infection that affects the eyes in people with AIDS. The condition is also known as CMV retinitis. This medicine also used to prevent cytomegalovirus infection in people who had an organ transplant from a CMV positive donor.

CMVretinitis is a serious viral eye infection of the retina. It is most oftenfound in people with weakened immune systems. The retina is the light-sensingnerve layer that lines the back of the eye. This condition is caused by thecytomegalovirus which is one of the herpes viruses that infects most adults.The vast majority of people who have cytomegalovirus have no symptoms ofinfection. They will never have any problems because of the virus. But in peoplewith weakened immune systems, the virus can reactivate and spread to theretina. This can lead to vision-threatening eye problems. 

Thesymptoms of CMV retinitis can begin with a slow onset of floaters with blurredvision over a few days. This can lead to a loss of peripheral vision.Sometimes, the symptoms begin with a blind spot in the center of vision.Wherein, it may lead to a loss of central vision. The symptoms usually happenfirst in one eye but often progress to the other eye. People with CMV retinitisoften develop a detached retina.

AIDS is thelate stage of HIV infection. This happens when the immune system of the body isbadly damaged because of the virus. A person with HIV is considered to haveprogressed to AIDS when;

  • They develop one or more opportunistic infections regardless of their CD4 count
  • The number of their CD4 cells falls below 200 cells per cubic millimeter of blood 

WithoutHIV medicine, people with AIDS typically survive for about 3 years. If someonehas a dangerous opportunistic illness, life expectancy without treatment fallsto about 1 year. HIV medicine can still help people at this stage of HIVinfection and it can even be lifesaving. 

How doesValganciclovir work for CMV infection?

Valganciclovirworks by blocking the action of an enzyme called DNA polymerase that is foundin the CMV virus. This enzyme is required by the virus for it to copy geneticmaterial. The virus must multiply and survive. This medicine is alsoincorporated into the DNA of the virus. By blocking the action of DNApolymerase and disrupting viral DNA, Valganciclovir prevents CMV frommultiplying. This controls the infection and helps the immune system to dealwith it. 

CMV is amember of the herpes group of viruses. In healthy people, this common virusnormally produces symptoms milder than the common cold. However, in peoplewhose immune systems are compromised such as people with AIDS, or people whohave had an organ transplant, it can cause serious infection. It is because theimmune system cannot fight it. This is referred to as an opportunisticinfection. In immunocompromised people, infection with CMV can lead tocomplications such as a condition called CMV retinitis. In CMV retinitis thevirus causes severe inflammatory changes in the retina of the eye, which canlead to blindness.

How touse Valganciclovir?

Take thismedication with food usually1-2 times a day. Each dose should be taken by mouthas a whole with a full glass of water. Wash your hands well before and aftertaking the medicine. Avoid contact with broken or crushed tablets on your skin,mucous membrane, and eyes. Also, avoid breathing in the dust from the tablets.If contact occurs, wash the area thoroughly with soap and water. If themedication gets in your eyes, rinse them thoroughly with plain water. 

Thedosage is based on your medical condition and response to the treatment. Inchildren, the dosage is also based on their body size. The doctor should keeptrack of your child’s height and weight. It is to make sure that the dose isright for them. This medication works best when the amount of drug in your bodyis kept at a constant level. You should take this at the same time and in thesame way each day. Continue taking Valganciclovir exactly as prescribed by yourdoctor. Do not change your dose or stop taking it even for a short time unlessdirected by your doctor. Changing or skipping your dose without approval fromyour doctor may increase the risk of side effects or make the infectionworse. 

What arethe side effects of Valganciclovir?

Commonside effects:

  • Upset stomach
  • Diarrhea
  • Loss of balance or coordination
  • Dizziness
  • Unsteadiness
  • Drowsiness
  • Shaking
  • Constipation
  • Diarrhea
  • Cold symptoms such as sneezing, stuffy nose, cough,or sore throat 

Tell yourdoctor if you have these serious side effects:

  • Changes in the amount of urine
  • Seizures 
  • Mental/mood changes 

If theseside effects persist or get worse, call for medical helps right away. 

Precautions 

  • This medicine may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you.
  • This medicine can sometimes cause a decrease in the normal amounts of blood cells in the blood. You will need to have regular blood tests to check your blood cells during your treatment.
  • Valganciclovir has the potential to cause cancers and to reduce fertility in men and women. It will only be used when the benefits of using it outweigh any possible risks. You should discuss this with your doctor.
  • Valganciclovir can cause birth defects if it is taken during pregnancy or if men taking it father a child. Women taking this medicine must use effective contraception to avoid getting pregnant during treatment. Men taking this medicine should use barrier contraceptives to prevent fathering a child both during and for at least three months following treatment. 
  • Valganciclovir is used in a lower dose or with extra monitoring in people with kidney or liver problems, low levels of white blood cells, history of blood disorders, or those who are receiving radiotherapy treatment. 
  • This is not recommended for use in people who are allergic to this drug and those with hemodialysis for kidney failure.