Sulfinpyrazone

Sulfinpyrazone

Sulfinpyrazone is used to prevent gout and gouty arthritis. A gout is a form of arthritis that can affect anyone. It is characterized by sudden or severe attacks of pain, swelling, redness or tenderness in the joints. It often attacks the joint at the base of the big toe. An attack of gout can happen suddenly; when you wake up in the middle of the night with the sensation that your big toe is on fire. The affected joint is swollen, hot, and tender. The signs and symptoms of this condition almost always occur suddenly, often at night. They include:

  • Limited range of motion – as gout develops, you may not be able to move your joints normally 
  • Inflammation and redness – the affected joint or joints become tender, swollen, red, and warm 
  • Lingering discomfort – after the most severe pain subsides, some joint discomfort may last form a few days to a few weeks. 
  • Intense joint pain – gout usually affects the large joint of your big toe but it can occur in any joint. The pain is likely to be most severe within the first 4 – 12 hours after it begins. 

Gouthappens when urate crystals mount up in your joint. Wherein, it causesinflammation and intense pain of a gout attack. Urate crystals can form whenyou have high levels of uric acid in your blood. When it breaks down purines,your body creates uric acid. Purines are substances found naturally in yourbody. Usually, uric acid dissolves in your blood and passes through yourkidneys into your urine. But at times either your body creates excessive uricacid or your kidneys excrete little uric acid as well. Once this occurs, uricacid can build-up and forms a sharp urate crystal in a joint or surroundingtissue that causes inflammation, pain, and swelling.

Sulfinpyrazoneis in the class of medications called uricosurics. This helps the kidneys toget rid of uric acid and lowers the high levels of uric acid. Lowering uricacid levels helps your kidney. This also prevents crystals from forming. TheFood and Drug Administration (FDA) has already approved Sulfinpyrazone. Thiscomes as a capsule with the dosage strengths of 100 mg and 200 mg for oraluse.  

How doesSulfinpyrazone work?

Sulfinpyrazoneworks by increasing the amount of uric acid that is filtered out of the bloodinto the urine by the kidneys. This lowers the level of uric acid in the blood.Therefore, it prevents the formation of crystals that causes flare-ups of gout. 

Uric acidis a chemical produced once the body breaks down elements. These are calledpurine which are usually made in the body and are also found in some foods anddrinks. When purines are broken down to uric acid in the blood, the body getsrid of it when you urinate or have a bowel movement. But if your body makes toomuch uric acid or if your kidneys aren’t working well, uric acid can build upin the blood. 

How touse Sulfinpyrazone?

Sulfinpyrazoneis to be taken by mouth. You may take it with food, milk, or antacids todecrease stomach upset. The medication is usually taken twice a day or asdirected by your doctor. To prevent kidney stones, it is best to drink a fullglass of water with each dose and at least another 8 glasses a day while takingSulfinpyrazone.Your doctor may instruct you on how to lessenacidity in your urine to prevent kidney stones. 

Thedosage of this prescription is based on your medical condition and response tothe treatment. Your doctor may direct you to take a low dose at first andadjust your dose based on your uric acid levels and gout symptoms. If you aretaking other medications such as cholestyramine, take this drug at least anhour before or 4 to 6 hours after cholestyramine. You may as well consult yourdoctor for more information. 

Treatmentwith Sulfinpyrazone should not be started during a sudden or severe goutattack. Wait until your current attack is over before starting this medication.It may cause an increase in the number of gout attacks for several months afterstarting this medicine while the body removes extra uric acid. If you have agout attack while taking Sulfinpyrazone, continue taking it along with yourmedications for gout pain. Use this medication regularly for the best benefit.Take it at the same time and in the same way each day. 

What arethe side effects of Sulfinpyrazone?

  • Loss of appetite
  • Nausea and vomiting
  • Joint swelling, pain, or redness
  • Sore throat
  • Tightening in the chest
  • Difficulty breathing
  • Skin rash
  • Mouth sores
  • Painful urination
  • Change in the amount of urine 
  • Lower back or side pain
  • Swollen or painful glands
  • Fever

If theseside effects persist or get worse, call your doctor right away. 

Warningsand Precautions

  • While taking Sulfinpyrazone, you should have regular blood tests to monitor the levels of blood cells in your blood. Your kidney function should as well be regularly monitored. 
  • This medication should be used with caution in people with heart disease, kidney disease, or a history of kidney stones.
  • This should not be used in people with acute gout, severe kidney or liver problems, or with a history of disturbances in the normal numbers of blood cells in their blood. 
  • Sulfinpyrazone is also not recommended for use in people with peptic ulcers, blood clotting problems, or blood disorders called porphyrias.  
  • If you already had an allergic reaction with this drug, tell your doctor right away. Inform as well if you have any allergies. This drug may have an ingredient that causes an allergic reaction. 
  • This is not suitable for use in children. 
  • Certain medications should not be used during breastfeeding or pregnancy. On the other hand, other medications may be safely used in breastfeeding or pregnancy providing the benefits to the mother outweighs the risks to the unborn baby. Always inform your doctor if you are planning a pregnancy or pregnant, before using any medicine.