Sorafenib

Sorafenib

Where is Sorafenib used?

Sorafenib is used for the treatment of advanced renal cell carcinoma which is a type of cancer that begins in the kidneys. This can also be used in hepatocellular carcinoma which is a type of liver cancer. This medication is used if cancer cannot be treated with surgery and radioactive iodine. Sorafenib is in the class of medications known as multi-kinase inhibitors that block the action of an abnormal protein that signals cancer cells to multiply. The Food and Drug Administration (FDA) has already approved this prescription for oral use.

How does Sorafenib work?

Sorafenib works by stopping the action of several kinase enzymes. This stops the signals that tell the cancer cells to develop and increase. It also stops blood vessels from growing into the tumor. This decreases the tumor’s blood supply and along with it is the supply of oxygen and nutrients. Both these effects stop the tumor from growing.

The approach that cells in the body works and develops is controlled by countless enzymes called kinases. In cancerous cells, these kinases make the cells develop abnormally and stimulate near blood vessels to progress into the tumor. The new blood vessels let the cancer cells grow and multiply by supplying them with oxygen and nutrients. They also permit the cancerous cells to spread into other areas of the body through blood circulation.

How is Sorafenib taken?

  • This medicine is usually taken twice a day
  • Each dose is taken on an empty stomach at least 1 hour or 2 hours before meal
  • Take the medicine by mouth with a glass of water
  • Take at about the same time each day

The recommended dosage is based on your medical condition and response. You must take this medication exactly as it is prescribed. You should not take more or less or more often than it is given by your doctor. Take each dose exactly as it is given by your doctor. Let your doctor know if your condition does not improve or if it gets worse.

What are the possible side effects of Sorafenib?

  • Nausea
  • Tiredness
  • Diarrhea
  • Vomiting
  • Patchy hair loss or thinning
  • Stomach pain
  • Hoarseness 
  • Loss of appetite
  • Dry mouth

Tell your doctor right away if you notice skin problems especially on the palms of your hands and soles of your feet such as:

  • Pain
  • Swelling
  • Redness
  • Rash

What are the precautions in taking Sorafenib?

  • If you are a pregnant or breastfeeding woman, consult your doctor first. This could be harmful to a developing baby.
  • Your capability to get pregnant or father a child may be affected by treatment with this medicine. It is important to discuss fertility with your doctor before starting treatment.
  • Sorafenib should be used with caution in elderly people, severely decreased liver function, those with high blood pressure, or a history of a heart attack. People at increased risk of bleeding or with blood clotting problems should need to be watchful when using this medicine. 
  • Let your doctor know if you ever had heart disease, liver disease, or bleeding problems. If you experience any chest pain as well, contact your doctor. 
  • Your blood pressure should be regularly monitored. If your blood pressure increases you may need to take medicines to reduce it.
  • This medicine should not be used if you are allergic to one or any of its ingredients.
  • If you are taking any vitamins or herbal supplements, inform your doctor.