Ecallantide is used for the treatment of an acute attack called hereditary angioedema (HAE). That is of a certain immune disease passed down through families. This medication may lessen the symptoms of this condition like rapid swelling and pain of the feet, hands, face, limbs, tongue, or throat. When attacks involve the intestines, symptoms may be diarrhea or vomiting and abdominal pain/cramps.
HAE is a disorder characterized by recurrent episodes of severe swelling. The most common area of the body to develop is swelling in the face, limbs, airway, and intestinal tract.
How does Ecallantide work?
Ecallantide blocks an enzyme inthe blood called kallikrein. Kallikrein is a part of a complex network ofproteins that has several effects in the body. One of which results inincreased levels of a protein called bradykinin. It causes the blood vessels towiden and leak fluid into the surrounding tissue. This leakage of fluids causesthe swelling attacks seen in angioedema. By blocking the actions of kallikrein,this drug is expected to help lessen the swelling and related symptoms ofangioedema.
Ecallantide is produced by a method known as recombinant DNA technology. It is made by a cell that has received a gene (DNA) which makes the cell able to produce it. This medication is for injection, subcutaneous use. Each vial contains 10 mg of Ecallantide as an active ingredient. A 30 mg dose is supplied as 3 vials each have 1 ml of 10 mg Ecallantide. This product has the brand name of Kalbitor. The Food and Drug Administration (FDA) has already approved this medication.
How to use Ecallantide?
This prescription is to be givenby your doctor or healthcare professional. This is to be injected under yourskin either in the thigh, abdomen, or upper arms. You may receive three shotsthat are separated by at least 2 inches. An additional three shots may be givenin a 24-hour period. It is if the HAE attack continues. The dosage is based onyour medical condition and response.
What are the side effects of Ecallantide?
- Sore throat
- Tired feeling
- Injection site reactions (pain, rash, irritation,redness, bruising, or itching)
Warnings and Precautions
- Do not receive an injection into the skin that istender, hard, or red.
- Tell your doctor if you are allergic to thismedication or if you have any allergies.
- Let your doctor know if your condition does notimprove or if it gets worse.
- This prescription may not be recommended forpregnant women. If you are breastfeeding women, consult your doctor r first.
- Inform your doctor if you have any medicalhistory.