Dextromethorphan Hydrobromide and Quinidine Sulfate

Active Ingredients

General Information

Dextromethorphan Hydrobromide and Quinidine Sulfate are indicated to treat pseudo-bulbar affect (PBA). PBA or emotional incontinence is a type of emotional disturbance. It is characterized by uncontrollable episodes of crying or laughing. It happens secondary to a neurologic disorder or brain injury. This condition may occur due to various conditions that affect the brain such as:

  • Amyotrophic lateral sclerosis
  • Stroke
  • Multiple sclerosis

How do Dextromethorphan Hydrobromide and Quinidine Sulfate work?

Dextromethorphan Hydrobromide and Quinidine Sulfate are believed to help regulate excitatory neurotransmission in two ways:

  • Through pre-synaptic inhibition of glutamate release via sigma-1 receptor agonist activity
  • Through postsynaptic glutamate response modulation via uncompetitive and low-affinity NMDA antagonist activity

Dextromethorphan Hydrobromide acts on the central nervous system. Quinidine Sulfate increases the systemic bioavailability of dextromethorphan.

Why use Dextromethorphan Hydrobromide and Quinidine Sulfate?

This product is a combination of two ingredients: Dextromethorphan Hydrobromide and Quinidine Sulfate. These help decrease sudden outbursts of uncontrollable or inappropriate laughing or crying. This medication is supplied as capsules for oral use. Each capsule contains 10 mg of Quinidine Sulfate and 20 mg of Dextromethorphan Hydrobromide. This has already been approved by the Food and Drug Administration (FDA).

How to use Dextromethorphan Hydrobromide and Quinidine Sulfate?

The recommended dosage is based on your condition, age, and response. You must take this drug exactly as it is prescribed. Take this regularly for the best benefit.

This prescription is usually taken once every 12 hours. The capsule is to be taken by mouth with a full glass of water. After taking the medicine, do not lie down for at least 10 minutes. Remember to take it at the same time each day. Let your doctor know if your condition does not improve or it gets worse.

What are the side effects of Dextromethorphan Hydrobromide and Quinidine Sulfate?

  • Gas
  • Diarrhea
  • Muscle spasm
  • Stomach pain
  • Weakness
  • Dizziness
  • Cough
  • Vomiting
  • Drowsiness
  • Feeling like you have flu
  • Swelling of your hands or feet and ankles
  • Dark urine
  • Easy bruising or bleeding

Warnings and Precautions

  • Before using this drug, tell your doctor if you are allergic to it.
  • Inform also your doctor if you have medical history especially of liver disease, blood/bone marrow, or kidney disease.
  • This drug may make you dizzy. Do not drive or use any machinery until you can do it safely.
  • This may not be recommended if you are pregnant. Consult your doctor if you are breastfeeding.
  • Keep this at a dry and clean place.