General Information

Anakinra is used for the treatment of rheumatoid arthritis. This helps to slow joint damage and lessens joint pain or swelling caused by rheumatoid arthritis. It is to help you move better.

Anakinra is also used to treatNeonatal-Onset Multisystem Inflammatory Disease (NOMID). This medication helpsto improve symptoms of the disease such as:

  • Rash
  • Fever
  • Vomiting
  • Joint pain
  • Headache

How does Anakinra work?

Anakinra is a synthetic andinjectable that blocks the effects of human interleukin-1 (IL-1). It is by competitively inhibiting IL-1binding to the interleukin-1. In which it is expressed in a wide variety oftissues and organs.

Patients withrheumatoid arthritis have elevated levels of IL-1. In rheumatoid arthritispatients, the levels of the naturally occurring IL-1Ra are not enough tocompete with the elevated amount of locally produced IL-1. Increasing thelevels of IL-1Ra by synthetic means lessens the negative of IL-1. It is calledcartilage degradation and bone resorption.

Why use Anakinra?

Anakinra is a man-made form of a natural protein made by the body. This medication is an interleukin-1 (IL-1) receptor, antagonist. This helps to block the effects of another protein which can cause joint swelling, pain, or stiffness.

This product has the brand nameof Kineret. This is supplied in a single-use prefilled glass syringe. It iswith 29 gauges needles as a sterile, clear-to-white, and preservative-freesolution for subcutaneous use. The Food and Drug Administration (FDA) hasalready approved this prescription.

How to use Anakinra?

This medication is injected underthe skin usually once a day. The dosage is based on your medical condition andresponse to it. Let the medication warm to room temperature for 30 minutesbefore injecting it.

Clean the injection site withrubbing alcohol before injecting it. Do not inject this medication in an areathat is tender, bruised, red, hard, or which has scars or stretch marks. It isimportant to change the location of the injection site daily to avoid problemareas under the skin. Do not inject this yourself. If you do not understand howto use the medicine properly, call your doctor.

What are the side effects of Anakinra?

  • Bruising
  • Redness
  • Pain at the injection site
  • Diarrhea
  • Nausea
  • Headache
  • Stomach pain
  • Cold symptoms such as sneezing, sore throat, orstuffy nose

Warnings and Precautions

  • Do not use the medication if it has changed color,looks cloudy or has particles in it.
  • Tell your doctor if you had an allergic reaction.
  • Call your doctor right away if your condition doesnot improve or if they get worse while using this drug.
  • You should not reuse the syringe. Learn how tokeep and discard needles safely.
  • While having this medication, do not havevaccinations or immunizations without the consent of your doctor.